Details

Methods and Biostatistics in Oncology


Methods and Biostatistics in Oncology

Understanding Clinical Research as an Applied Tool

von: Raphael. L.C Araújo, Rachel P. Riechelmann

107,09 €

Verlag: Springer
Format: PDF
Veröffentl.: 16.04.2018
ISBN/EAN: 9783319713243
Sprache: englisch

DRM-geschütztes eBook, Sie benötigen z.B. Adobe Digital Editions und eine Adobe ID zum Lesen.

Beschreibungen

This book introduces and discusses the most important aspects of clinical research methods and biostatistics for oncologists, pursuing a tailor-made and practical approach. Evidence-based medicine (EBM) has been in vogue in the last few decades, particularly in rapidly advancing fields such as oncology. This approach has been used to support decision-making processes worldwide, sparking new clinical research and guidelines on clinical and surgical oncology. Clinical oncology research has many peculiarities, including specific study endpoints, a special focus on survival analyses, and a unique perspective on EBM. However, during medical studies and in general practice, these topics are barely taught. Moreover, even when EBM and clinical cancer research are discussed, they are presented in a theoretical fashion, mostly focused on formulas and numbers, rather than on clinical application for a proper literature appraisal. Addressing that gap, this book discusses more practical aspects of clinical research and biostatistics in oncology, instead of relying only on mathematical formulas and theoretical considerations. Methods and Biostatistics in Oncology will help readers develop the skills they need to understand the use of research on everyday oncology clinical practice for study design and interpretation, as well to demystify the use of EBM in oncology.
PrefaceAuthor: Mithat Gönen – chief of biostatistics department of Memorial Sloan-Kettering Cancer Center – NY – USA.Background of scientific method in oncologyAuthor: Vinícius Vazquez – Surgical oncologist – Barretos Cancer Hospital, Barretos, São Paulo, BrazilWriting a hypothesis for a oncology studyAuthor: Felipe Fregni, Harvard Medical SchoolType of variables and distributionsAuthor: Gregory Pond, MacMaster, Hamilton, ON, CanadaTesting measures of associationAuthor: To be definedSample size calculation for oncology trialsAuthor: Ulrich Güller, Kantonsspital St. Gallen, 9007, St Gallen, Switzerland. ulrich.gueller@kssg.chUni and multivariate analysis (understanding of regressions) in cancer researchAuthor: Marc Buyse, EORTC Survival analyses in cancer trialsAuthor: Daniel Sargent, Mayo ClinicThe role of transversal and cohort studies in oncologyAuthor: To be definedDesign of retrospective and case-control studies in oncologyAuthor: To be definedMinimizing differences by randomizationAuthor: To be definedHow to design phase I trials in oncologyAuthor: Lillian Siu, Princess Margert Hospital, Toronto, ON, Canada ou Carlos Gil, INCAThe many different designs of phase II oncology trialsAuthor: Gilberto de Castro e Paulo Hoff?Superiority and non-inferiority phase III oncology trialsAuthors: Everardo Saad, (affiliation TBD)Phase IV oncology trials Author:Analysis of graphs in clinical cancer researchAuthor: Raphael Araujo – Upper GI and HPB Surgery department;  Barretos Cancer Hospital, Barretos, SP, BrazilIdentifying biases in clinical cancer researchAuthor: Rachel Riechelmann, Instituto do Cancer do Estado de Sao Paulo, Universidade de São PauloEthics in clinical cancer researchAuthor: Rodrigo GuidaliniCost-effectiveness studies in oncologyAuthor: Ian Tannock, Princess Margert Hospital, Toronto, ON, CanadaHow to undertake outcomes research in oncologyAuthor: Christopher Booth,  NCI Canada, Kingston, ONSystematic review and meta-analysis of oncology studiesAuthor: André SasseMeta-research in oncologyAuthor: Everardo SaadAnalysis of quality of life and patient-reported outcomes in oncologyAuthor: Janette Vardy, University of Sidney, AustraliaExercisesCommented answersGlossary
Raphael L. C. Araujo is a Surgical Oncologist specialized in the diagnosis and treatment of malignant and benign injuries of the liver, pancreas and colorectal liver metastases. He spent two years (2010 / 2012) as a Research Fellow at the Hepatopancreatobiliary Service of the Memorial Sloan-Kettering Cancer Center in New York (USA). During this time, he worked on clinical research of surgical and systemic treatment of pancreatic cancer and colorectal liver metastases. Afterwards, he also spent one year as a resident of the Hepatopancreatobiliary Service at the Hospital Paul Brousse, France (2012/2013). Dr. Araujo received a PhD and concluded his postdoctoral research in Gastroenterology from the University of São Paulo School of Medicine, the same institution where he worked for 2 years as an attending physician in the Liver Surgery Unit. He is currently head of the Department of Upper Gastrointestinal and Hepato-Pancreato-Biliary Surgery and Professor of the Post Graduation Program of Barretos Cancer Hospital, Barretos, São Paulo, Brazil, and Scientific Director of Brazilian Society of Surgical Oncology.Rachel P. Riechelmann is a medical oncologist and researcher in the field of gastrointestinal cancers. She completed her formal training and PhD at the Federal University of Sao Paulo, followed by a clinical research fellowship at Princess Margaret Hospital, University of Toronto, Canada. She is currently the Director of the Department of Oncology at AC Camargo Cancer Center,  which is one of the largest academic cancer centers in Brazil and Latin America, and Research Director of the Brazilian Gastrointestinal Tumors Group. Research- wise, her areas of interest and expertise are GI malignancies and Neuroendocrine Tumors as well as Methodology of Clinical Research. She has 78 publications in peer-reviewed journals and several PhD students and oncology fellows conducting projects under her supervision. 
This book introduces and discusses the most important aspects of clinical research methods and biostatistics for oncologists, pursuing a tailor-made and practical approach.Evidence-based medicine (EBM) has been in vogue in the last few decades, particularly in rapidly advancing fields such as oncology. This approach has been used to support decision-making processes worldwide, sparking new clinical research and guidelines on clinical and surgical oncology. Clinical oncology research has many peculiarities, including specific study endpoints, a special focus on survival analyses, and a unique perspective on EBM. However, during medical studies and in general practice, these topics are barely taught. Moreover, even when EBM and clinical cancer research are discussed, they are presented in a theoretical fashion, mostly focused on formulas and numbers, rather than on clinical application for a proper literature appraisal.Addressing that gap, this book discusses more practical aspects of clinical research and biostatistics in oncology, instead of relying only on mathematical formulas and theoretical considerations. Methods and Biostatistics in Oncology will help readers develop the skills they need to understand the use of research on everyday oncology clinical practice for study design and interpretation, as well to demystify the use of EBM in oncology.
A tailor-made book on clinical research and biostatistics in oncologyFocuses on practical and applicable knowledge and usefulness in daily practice, allowing readers to properly appraise literatureAll chapters and examples are contextualized to oncologyIntended for surgical and clinical oncologists, researchers, students and professors in the field
A tailor-made book on clinical research and biostatistics in oncology.Focuses on practical and applicable knowledge and usefulness in daily practice, allowing readers to properly appraise literature.All chapters and examples are contextualized to oncology.Intended for surgical and clinical oncologists, researchers, students and professors in the field.

Diese Produkte könnten Sie auch interessieren:

Medikamenten-Pocket Schmerztherapie
Medikamenten-Pocket Schmerztherapie
von: Ingolf Cascorbi, Jürgen Sorge, Michael Strumpf
PDF ebook
19,99 €
Lasers in Dermatology and Medicine
Lasers in Dermatology and Medicine
von: Keyvan Nouri
PDF ebook
214,19 €
Psiquiatría clínica deportiva
Psiquiatría clínica deportiva
von: David A. Baron, Claudia L. Reardon, Stephen H. Baron, Prof. Steve Peters
EPUB ebook
24,99 €